St. Mary's (known as Negeqliq in Central Yup'ik language) is a city in Kusilvak Census Area, Alaska, United States. It is located at 62°2?43?N 163°13?7?W and is spread across a total area of 50.2 square miles. Geographically, the city comprises of 44.0 square miles of land and 6.3 square miles water.
In 1980, the adjacent village of Andreafsky (also known as Clear River) was joined with the city. Visitors would find that there are two federally-recognized tribes in the city, and they are the Algaaciq Tribal Government and the Yuupiit of Andreafsky.
The city is served by St. Mary's Airport (IATA: KSM). It is a public airport located 4 miles 6 km) west of the central business district of St. Mary's. It offers scheduled flights to other Alaskan destinations like Alakanuk, Anchorage, Aniak, Bethel, Emmonak, Kotlik, Mountain Village, Nunam Iqua/Sheldon Point and Pilot Station through Ravn Alaska airline.